منابع مشابه
FNDC5/Irisin Is Not Only a Myokine but Also an Adipokine
Exercise provides clear beneficial effects for the prevention of numerous diseases. However, many of the molecular events responsible for the curative and protective role of exercise remain elusive. The recent discovery of FNDC5/irisin protein that is liberated by muscle tissue in response to exercise might be an important finding with regard to this unsolved mechanism. The most striking aspect...
متن کاملWISP1 is a novel adipokine linked to inflammation in obesity.
WISP1 (Wnt1-inducible signaling pathway protein-1, also known as CCN4) is a member of the secreted extracellular matrix-associated proteins of the CCN family and a target gene of the Wingless-type (WNT) signaling pathway. Growing evidence links the WNT signaling pathway to the regulation of adipogenesis and low-grade inflammation in obesity. We aimed to validate WISP1 as a novel adipokine. Huma...
متن کاملSerum fetuin-A is an independent marker of insulin resistance in Japanese men.
AIM Fetuin-A, also known as alpha2-Heremans Schmid glycoprotein, is an abundant plasma protein synthesized predominantly in the liver. Fetuin-A inhibits insulin receptor autophosphorylation, which is mediated by its intrinsic tyrosine kinase activity. In this study, we examined the association between the serum fetuin-A level and insulin resistance in Japanese men. METHODS We recruited 300 un...
متن کاملAdiponectin: an adipokine with protective features against metabolic syndrome
Metabolic syndrome (MetS) as a collection of obesity-associated disorders is associated with inflammation, oxidative stress, pro-thrombotic state, elevated risk of developing cardiovascular disease and type 2 diabetes. Adiponectin is one of the most abundant peptide hormones derived from adipose tissue. This protein plays a major role in glucose and lipid metabolism and prevents development of ...
متن کاملVisfatin: an adipokine that plays a crucial role in increasing the risk of cancer
Obesity is an important public health problem worldwide. Epidemiological studies have demonstrated that obesity is associated with an increased risk of several cancer types. Also, obesity is associated with an increase in cancer mortality. Biological mechanisms and the relationship between obesity and cancer are complex and not well understood. Studies on the role of adiposederived factors in c...
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ژورنال
عنوان ژورنال: Lipids in Health and Disease
سال: 2019
ISSN: 1476-511X
DOI: 10.1186/s12944-019-1021-8